Endocrine Abstracts

IntroductionHyperlactatemia is defined by a lactate value > 2 mmol/l and a lactate value above > 4 mmol/l is commonly used to define more severe hyperlactatemia. It is a common disorder in critically ill patients, associated with adverse prognosis. Diabetes mellitus (DM), however, can also be associated with increased lactate levels at baseline.ObjectivesTo document the development of severe hyperlact...

A 65-year-old patient was hospitalized three times over a two-year period for severe acute pancreatitis. After the first hospitalization, cholecystectomy was performed. During the second hospitalization she was treated in the ICU because of the development of necrotizing emphysematous pancreatitis with the development of sepsis. During the third hospitalization the patient presents clinically with general weakness, agitation, visual hallucinations, disorientation and damaged c...

Aim of the study: To examine the influence of sitagliptin in patients treated with a diabetic diet and metformin, on metabolic parameters and kidney function after three months of sitagliptin therapy.Subjects and methods: 35 patients (19 men and 16 women) were included in the study. Sitagliptin was introduced in patients on a diabetic diet and metformin with HbA1c≥6.5%. Fasting and postprandial plasma glucose value, HbA1c, cholesterol, HDL, LDL, tr...

Objectives: Maternal hypothyroidism in pregnancy has been proposed to increase the risk of preeclampsia, but uncertainties persist regarding the underlying causal mechanisms. Thus, it remains unclear if an increased risk of preeclampsia in hypothyroid pregnant women is caused by the lack of thyroid hormones or by the thyroid autoimmunity per se.Methods: We performed a national and regional study in the Danish population. The national study was r...

Introduction: Insulin is standard of care for the treatment of type 1 diabetes (T1DM). Constant insulin adjustment is necessary to keep up with the different insulin requirements of pregnancy. Rapid, flexible and precise dosing of basal insulin and advanced options of bolus calculator settings for prandial insulin make insulin pump optimal solution.Aim: The aim of the study was to explore pattern of insulin dynamic in pregnancies of T1DM patients with ti...

Introduction: Despite basal-bolus regime many type 2 diabetic patients do not achieve good glycemic control. Obesity and a large number of insulin units per day, even in combination with metformin and/or SGLT-2 inhibitors, are challenge in treatment of those patients.Aim: To assess changes of glycemia, body weight and daily dose of insulin in a group of type 2 diabetic patients treated with basal-bolus scheme (with/without peroral agents), starting with ...

Introduction: Depression is the leading cause of disability worldwide, and is a major contributor to the overall global burden of disease. People with DM have 2.4–4.3 times greater risk of depression than people without DM as well as patients (pts) treated with insulin. Women experience depression more often than men. Symptoms of depression can make it more difficult to successfully manage diabetes and prevent diabetes-related complications.Material...

Background: Classical congenital adrenal hyperplasia (CAH) is diagnosed mainly in newborns. While patients with salt wasting form cannot survive without timely diagnosis, those with simple virilizing or nonclassical may be diagnosed even in advanced age.Aim: To present clinical, biochemical, radiological and genetic characteristics of series of CAH patients diagnosed in advanced adulthood.Material and methods: Eight patients (F=5, ...

Introduction: In patients with non-controlled type 2 diabetes mellitus (DM2) and obesity treated with oral therapy, liraglutide treatment should improve glycemic and metabolic control.Materials and methods: Retrospective descriptive study. Liraglutide treatment was started in 46 outpatients with uncontrolled DM2. The effect of therapy was evaluated between September 2013 and January 2016. Age, sex, duration of diabetes, weight, BMI, HbA1c, fasti...

Evidences for a functional link between insulin receptor (IR) and β2-adrenergic receptor (β2AR) exist in the mouse heart and in retina and are correlated with the cardiovascular dysfunction under insulin-resistant states1 and a diabetic retinopathy phenotype2. In our recent study we showed that i) IR coexpression reduced β2AR surface expression and accelerated its internalization, ii) provided evidence for d...